A recent clinical study shows these weight loss drugs may do more than shrink your waistline—they can boost your testosterone, too.
GLP-1 medications like semaglutide (Ozempic®/Wegovy®) and tirzepatide (Mounjaro®/Zepbound®) are already well-known for their incredible impact on weight loss. But a 2025 study presented at the Endocrine Society’s annual meeting confirms what many men have been hoping: These medications can also raise your testosterone levels.
Over the course of 18 months, researchers tracked 110 men using GLP-1s. None were on TRT. After sustained weight loss (an average of 10% body weight), the number of men with normal testosterone levels jumped from 53% to 77%. That’s a major win.
Why It Works: The Weight Loss-Hormone Connection
The study didn’t show that GLP-1s directly boost testosterone production. Instead, they set the stage for your body to start producing more of its own. Here’s why:
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Less body fat = less testosterone being converted into estrogen
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Improved insulin sensitivity = better hormone signaling
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Lower inflammation = better testicular function
In short, weight loss helps unlock your natural hormone potential—and GLP-1s are one of the most effective tools we have to get you there.
So, Are GLP-1s a Replacement for TRT?
Not quite. If you’ve already been diagnosed with low testosterone and your levels aren’t improving, TRT may still be the best solution for long-term energy, libido, and strength.
But here’s the kicker: many men at Limitless Male see the biggest transformation when using GLP-1s alongside TRT. Together, they help you:
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Lose stubborn fat
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Boost testosterone (naturally and therapeutically)
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Preserve muscle
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Feel stronger, leaner, and more energized
The Bottom Line
Yes, semaglutide and tirzepatide can raise testosterone levels in men—especially those carrying extra weight. It’s not a gimmick. It’s real biology, backed by real science. However, it’s best to pair the two for optimal results.
Ready to Optimize Everything?
At Limitless Male, we personalize every plan—so whether you’re considering TRT, GLP-1s, or both, we’ll help you understand your numbers and create a strategy that actually works.
Take back your strength, your confidence, and your life.
